FibroMax
FibroMax is a new non invasive comprehensive “super biomarker” for the diagnosis of the most common liver diseases..It can achieve a 50% reduction in number of required liver biopsies.
FibroMax is actually five tests all in one, namely;
1) FibroTest
To asses the degree of fibrosis (scarring) following chronic Hepatitis C & B infection. Results are reported in stages
F0 : No Fibrosis
F1 : Portal Fibrosis
F2 : bridging fibrosis with few septa
F3 : bridging fibrosis with many septa
F4 : Cirrhosis
2) ActiTest
To asses the degree of activity (inflammation & necrosis) following chronic Hepatitis C & B infection.
Necroinflammatory activity is reported in grades
A0 : No activity
A1 : Minimal activity
A2 : Moderate activity
A3 : Severe activity
3) SteatoTest
To diagnose hepatic steatosis (fatty liver).
Results are expressed by a score
S0 : No steatosis
S1 : Minimal steatosis, less than 5% of hepatocytes with steatosis
S2 : Moderate steatosis, between 6-32% of hepatocytes with steatosis
S3 : Severe steatosis, between 33-100% of hepatocytes with steatosis
4) NashTest
To diagnose non alcoholic steatohepatitis (metabolic steatosis) due to overweight, diabetes, hyperlipidemia, insulin resistance, arterial hypertension, etc….. Diagnosis is expressed in groups
N0 : No Nash
N1 : Borderline
N2 : Nash
5) AshTest
To diagnose of severe alcoholic steatohepatitis.
Diagnosis is expressed in groups
H0 : No Ash
H1 : Minimal Ash
H2 : Moderate Ash
H3 : Severe Ash
FibroMax
Combines the measurement of 10 indirect parameters adjusted to age, sex, weight & height namely : Alpha 2-macroglobulin, Haptoglobin, Apolipoprotein A1, Total bilirubin, Gamma Glutamyl Transpeptidase (GGT), ALT, AST, Fasting glucose, Triglycerides & Total Cholesterol.
Patients must be fasting 12-14 hours
What are the most frequent causes of false positive results for Fibro test & Acti test?
* Hemolysis, which decreases haptoglobin as observed with ribavirin treatment,or cardiac prosthesis.
* Gilbert syndrome,which increase total bilirubin.
* Extra-hepatic cholestasis,which increases GGT and total bilirubin.
* Drugs which increase total bilirubin as atazanavir.
* Patients fasting less than 12-14 hours.
Follow up of positive cases is recommended once every 6 months
